Search results for " cell viability"

showing 5 items of 5 documents

New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens

2013

The synthesis and the in vitro antibacterial activity of novel linezolid-like oxadiazoles are reported. Replacement of the linezolid morpholine C-ring with 1,2,4-oxadiazole results in an antibacterial activity against Staphylococcus aureus both methicillin-susceptible and methicillin-resistant comparable or even superior to that of linezolid. While acetamidomethyl or thioacetoamidomethyl moieties in the C(5) side-chain are required, fluorination of the phenyl B ring exhibits a slight effect on an antibacterial activity but its presence seems to reduce the compounds cytotoxicity. Molecular modeling performed using two different approaches - FLAP and Amber software - shows that in the binding…

Methicillin-Resistant Staphylococcus aureusModels MolecularCell viabilityStaphylococcus aureusMolecular modelCell SurvivalMicrobial Sensitivity TestsAntimicrobial activityCrystallography X-Raymedicine.disease_causeDrug designMicrobiologyStructure-Activity Relationshipchemistry.chemical_compoundoxadiazoles linezolid antibioticsCell Line TumorDrug Resistance Multiple BacterialMorpholineAcetamidesDrug DiscoverymedicineHumansMoietyStructure–activity relationshipOxazolidinonesPharmacologyOxadiazolesOxazolidinones; Linezolid; Drug designDose-Response Relationship DrugMolecular StructureChemistryOrganic ChemistryLinezolidSettore CHIM/06 - Chimica OrganicaHep G2 CellsGeneral Medicinebiochemical phenomena metabolism and nutritionbacterial infections and mycosesSettore CHIM/08 - Chimica FarmaceuticaMethicillin-resistant Staphylococcus aureusCombinatorial chemistryOxazolidinoneAnti-Bacterial AgentsStaphylococcus aureusMED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICALinezolidAntimicrobial activity; Cell viability; Drug design; Oxazolidinones; Staphylococcus aureusAntibacterial activitySoftware
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The role of poly(ethylenglycol) molecular weight on viability and cell adhesion in polylactide based scaffolds

2011

Scaffolds PLA PEG cell viability
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AQUEOUS EXTRACTS FROM LEAVES AND RHIZOMES OF THE MARINE SEAGRASS POSIDONIA OCEANICA EXHIBIT ANTI-LIVER CANCER ABILITY IN VITRO

2022

cancer cells Poseidonia oceanica leaf extract rhizome extract cell viability cell cycle apoptosis autophagy cell locomotionSettore BIO/05 - ZoologiaSettore BIO/06 - Anatomia Comparata E Citologia
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In vitro effects of extracts from leaves and rhizomes of P.oceanica on HepG2 tumor cells

2023

cell biology tumor cells posidonia oceanica anticancer cytotoxic apoptosis autophagy cell viability mitochondria cell cycle redox state wound healing assaySettore CHIM/10 - Chimica Degli AlimentiSettore BIO/05 - ZoologiaSettore BIO/06 - Anatomia Comparata E Citologia
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Composition influence on pulmonary delivery of rifampicin liposomes.

2012

The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesic…

liposomesaerosolPhospholipidpulmonary deliveryPharmaceutical Sciencelcsh:RS1-441liposomes; rifampicin; cholesterol; oleic acid; rheology; pulmonary delivery; aerosol; cell viability; cellular uptakerifampicinArticlelcsh:Pharmacy and materia medicachemistry.chemical_compoundPhosphatidylcholineMedicinecell viabilityLiposomeChromatographyCholesterolbusiness.industryVesiclecholesterolcellular uptakeIn vitroOleic acidchemistryBiochemistryoleic acidToxicitylipids (amino acids peptides and proteins)rheologybusinessPharmaceutics
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